{"id":6914,"date":"2023-02-08T16:09:33","date_gmt":"2023-02-08T11:09:33","guid":{"rendered":"https:\/\/www.serenepharma.com\/?p=6914"},"modified":"2023-02-08T16:10:06","modified_gmt":"2023-02-08T11:10:06","slug":"bf-rivojlanish-xavfi-bilan-bogliq-otoimmun-kasalliklar","status":"publish","type":"post","link":"https:\/\/www.serenepharma.com\/uz\/gazetauz\/bf-rivojlanish-xavfi-bilan-bogliq-otoimmun-kasalliklar\/","title":{"rendered":"BF rivojlanish xavfi bilan bog\u2019liq otoimmun kasalliklar"},"content":{"rendered":"\n

kardiologiya bugun, 2023 yil 8-yanvar | Tilly MJ, va boshqalarning materiallari asosida moslashtirilgan. Europace. 2022;doi:10.1093\/europace\/euac244<\/p><\/blockquote>\n\n\n

\n
\"\"<\/a><\/figure>\n<\/div>\n\n\n

Ep Europace-da chop etilgan tadqiqotga ko\u2019ra, autoimmun kasalliklar bo\u2019lmagan fibrilatsiyaning yuqori xavfi bilan bog\u2019liq, ayniqsa ayollarda.<\/p>\n\n\n\n

2006 yildan 2022 yilgacha Britaniya biobank ma\u2019lumotlaridan foydalangan holda, BF bo\u2019lmagan 494,072 bemor (o\u2019rtacha yoshi 58 yosh; ayollarning 55%) revmatik isitma, oshqozon-ichak trakti (GI) autoimmun kasalliklari, mushak-skelet va biriktiruvchi to\u2019qimalarning autoimmun kasalliklari va nevrologik autoimmun kasalliklar uchun tahlil qilindi. Medianadan so\u2019ng, 12,8 yoshda, bemorlarning 5,5 foizida yangi paydo bo\u2019lgan BF tashxisi qo\u2019yilgan.<\/p>\n\n\n\n

\u201cBiz yangi paydo bo\u2019lgan BF va revmatik isitma o\u2019rtasida yurak shikastlanishisiz, oshqozon-ichak traktining
autoimmun kasalliklari (Kron kasalligi va yarali kolit) va mushak-skelet tizimi (revmatoid artrit, psoriatik va enteropatik artropatiyalar, tugunli Poliarterit, tizimli eritematoz va tizimli skleroz) o\u2019rtasida sezilarli bog\u2019liqlikni topdik. – dedi Martijn J. Rouling. Tilley, MD, Erasmus MC epidemiologiya bo\u2019limidan, Rotterdam universiteti tibbiyot markazi, Niderlandiya va hamkasblari yozgan. \u201cBundan tashqari, biz ushbu uyushmalardagi erkaklar va ayollar o\u2019rtasidagi sezilarli farqlarning dalillarini topdik.\u201d<\/p>\n\n\n\n

Tadqiqotchilar shuni aniqladilarki, bemorlarda yurak shikastlanishisiz revmatik isitma, (HR = 1.47; 95% CI, 1.26-1.72), Kron kasalligi (HR = 1.23; 95% CI, 1.05-1.45), yarali kolit (HR = 1.17; 95% CI, 1.06-1.31), revmatoid artrit (HR = 1.39; 95% CI, 1.28-1.51), tugunli Poliarterit (HR = 1.82; 95% CI, 1.04-3.09), tizimli qizil yuguruk (HR = 1.82; 95% CI, 1.41-2.35) yoki tizimli skleroz (HR = 2.32; 95% CI, 1.57-3.44) bo\u2019lsa, BF rivojlanish xavfi yuqori.<\/p>\n\n\n\n

Autoimmun kasalliklar, ayniqsa ayollarda BF rivojlanish xavfining ortishi bilan bog\u2019liq. Tadqiqotchilar shuni aniqladilarki, bemorlarda yurak shikastlanishisiz revmatik isitma (HR = 1.79; 95% CI, 1.45-2.2), Kron kasalligi (HR = 1.35; 95% CI, 1.05-1.73), mushak-skelet tizimining buzilishi (HR = 1.51; 95% CI, 1.38-1.66), revmatoid artrit (HR = 1.5; 95% CI, 1.35-1.67), psoriatik va enteropatik artropatiyalar (HR = 2.01; 95% CI, 1.32-3.05), tizimli qizil yuguruk (HR = 1.79; 95% CI, 1.34-2.4), tizimli skleroz (HR = 2.51; 95% CI, 1.64-3.85), Ankilozlanuvchi spondilit (HR = 1.53; 95% CI, 1.13-2.07) va tarqoq skleroz (HR = 1.37; 95% CI, 1.07-1.75) bo\u2019lsa, BF rivojlanish xavfi yuqori. Ularning barchasi ayollarda yangi paydo bo\u2019lgan BF bilan mazmunli uyushmalar edi. Umumiy aholida yangi paydo bo\u2019lgan BF bilan kasallanish darajasi 1000 kishiga 4,49 ni tashkil etgan bo\u2019lsa-da, bu ko\u2019rsatkich erkaklarda 1000 kishiga 6,25 va ayollarda 1000 kishiga
3,08 ni tashkil etdi.<\/p>\n\n\n\n

\u201cAutoimmun kasalliklar deyarli yarim million ishtirokchini o\u2019z ichiga olgan ushbu istiqbolli aholi tadqiqotida yangi BF xavfi bilan bog\u2019liq\u201d, deb yozadi Tilli va hamkasblari. \u201cBizning topilmalarimiz erkaklar va ayollar o\u2019rtasidagi autoimmun kasalliklarning patofiziologik farqlari haqidagi zamonaviy bilimlarni yanada rivojlantiradi va ularga hissa qo\u2019shadi.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

kardiologiya bugun, 2023 yil 8-yanvar | Tilly MJ, va boshqalarning materiallari asosida moslashtirilgan. Europace. 2022;doi:10.1093\/europace\/euac244 Ep Europace-da chop etilgan tadqiqotga ko\u2019ra, autoimmun kasalliklar bo\u2019lmagan fibrilatsiyaning yuqori xavfi bilan bog\u2019liq, ayniqsa ayollarda. 2006 yildan 2022 yilgacha Britaniya biobank ma\u2019lumotlaridan foydalangan holda, BF bo\u2019lmagan 494,072 bemor (o\u2019rtacha yoshi 58 yosh; ayollarning 55%) revmatik isitma, oshqozon-ichak trakti (GI)…<\/p>\n","protected":false},"author":1,"featured_media":6866,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","inline_featured_image":false,"footnotes":""},"categories":[141],"tags":[160],"class_list":["post-6914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gazetauz","tag-kardiologiya"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t